Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice
نویسندگان
چکیده
منابع مشابه
Interleukin-11 alters placentation and causes preeclampsia features in mice.
Preeclampsia (PE) is a pregnancy-specific disorder characterized by hypertension and proteinuria after 20 wk gestation. Abnormal extravillous trophoblast (EVT) invasion and remodeling of uterine spiral arterioles is thought to contribute to PE development. Interleukin-11 (IL11) impedes human EVT invasion in vitro and is elevated in PE decidua in women. We demonstrate that IL11 administered to m...
متن کاملAbnormal placentation and the syndrome of preeclampsia.
Preeclampsia, particularly the severe cases that occur early in pregnancy, is associated with defects in the (placental) cytotrophoblast differentiation pathway that leads to uterine invasion. At a morphologic level, interstitial invasion often is shallow. Perhaps more significantly, endovascular invasion, particularly the arterial component, is rudimentary. The latter defect is thought to lead...
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Background and Objectives: Febrile convulsion (FC) is the most common seizure disorder in childhood period. Some studies have suggested association between seasons and occurrence of FC. This study was designed to determine demographic features, causes and seasonal variations in cases with FC. Method: In this descriptive, cross sectional study, 282 children 6- 60 months with FC were admitted to ...
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Galectin-9 is a pleiotropic immune modulator affecting numerous cell types of innate and adaptive immunity. Patients with chronic infection with either hepatitis C virus (HCV) or HIV have elevated circulating levels. Limited data exist on the regulation of natural killer (NK) cell function through interaction with galectin-9. We found that galectin-9 ligation downregulates multiple immune-activ...
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Galectins are small unglycosylated soluble lectins distributed both inside and outside the cells. They share a conserved domain for the recognition of carbohydrates (CRD). Although galectins have a common affinity for β-galatosides, they exhibit different binding preferences for complex glycans. First described twenty years ago, galectin-7 is a prototypic galectin, with a single CRD, able to fo...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2020
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.120.15313